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KMID : 0363219690070010009
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Korean Journal of Dermatology
1969 Volume.7 No. 1 p.9 ~ p.24
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Experimental Study on The Role of Various Antihistaminics to Tissue Mast Cell Changes Elicited by Ultraviolet Ray Inflammation
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Houh Won
Kim Sung-Hwan
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Abstract
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In order to elucidate the mast cell changes challenged by various antihistaminic preparations and its role to the mast cells challenged by inflammation, male albino rats weighing 120130gm were used for this investigations.
Benadryl hydrochloride, Phenergan hydrochloride and Chlor-Trimeton maleate were .choosed for antihistaminic challengers and ultraviolet ray was irradiated for an inflammatory challenger.
1. When rats were challenged by various antihistaminics the numbers of mast cell reached -to the least after 2 days and later followed by an increasing mast cell numbers.
2. The mast cell changes were severer in order of Phenergan hydrochloride, Benadryl hydrochloride and Chlor-Trimeton maleate.
3. Degranulated mast cell was proportionally increased as the numbers of mast cell -decrease after being chalinged by antihistaminics and also it was decreasing when the numbers of mast cell were re-increasing (Rebound phenomena).
4. The mast cell changes were severer proportionally when inflammation was elicited by ultraviolet ray inspite of antihistaminics injections tha n the former solely antihistamine .challenged experiments.
5. The mast cell changes were severer in order of Phenergan hydrochloride. Benadryl hydrochloride and Chlor-Trimeton maleate when ultraviolet ray inflammation was elicited.
6. When inflammation was elicited by ultraviolet ray the other parts non-irradiated tissue mast cell numbers was also challenged severely, yet comparatively less than that site of direct irradiation.
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